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A plug-and-play microfluidic device for hydrogel fiber spinning.

Kongchang Wei1,2, Wuchao Wang1, Giorgia Giovannini1

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A novel plug-and-play microfluidic device simplifies hydrogel fiber spinning for biomedical applications. This user-friendly system enables easy fabrication of functional, multi-layered hydrogel fibers for biosensing and drug delivery.

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Area of Science:

  • Biomaterials Science
  • Microfluidics
  • Biomedical Engineering

Background:

  • Hydrogel fibers are vital for biosensing, drug delivery, and tissue engineering.
  • Existing microfluidic devices for hydrogel fiber spinning are complex, requiring specialized equipment and expertise.
  • Current devices are prone to issues like clotting and contamination, limiting user accessibility.

Purpose of the Study:

  • To develop a user-friendly, modular, plug-and-play microfluidic device for efficient hydrogel fiber spinning.
  • To overcome the limitations of conventional microfluidic systems in terms of fabrication complexity and maintenance.
  • To demonstrate the versatility of the device in producing various hydrogel fiber configurations, including multi-layered structures.

Main Methods:

  • Designed a modular plug-and-play microfluidic device using PDMS elastomers mounted on Lego® blocks.
  • Employed the device for alginate hydrogel fiber spinning using single, double, and triple-module configurations.
  • Fabricated pH-sensitive multi-layered hydrogel fibers as a proof-of-concept.

Main Results:

  • The plug-and-play device allows for easy assembly, disassembly, and module replacement, enhancing user-friendliness.
  • Successfully produced alginate hydrogel fibers using single and double-module setups.
  • Demonstrated the capability to create multi-layered hydrogel fibers with a triple-module device.
  • Fabricated pH-sensitive multi-layered fibers suitable for monitoring biological environments.

Conclusions:

  • The plug-and-play microfluidic device offers a simplified and accessible approach to hydrogel fiber fabrication.
  • The modular design facilitates maintenance and customization for diverse biomedical applications.
  • The developed system holds significant potential for advancing research in functional hydrogel fibers for biosensing and drug delivery.