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Neutrophils, NETs and multiple sclerosis: a mini review.
Moyuan Quan1,2,3, Huining Zhang1,2,3, Xiaohong Deng4
1Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Frontiers in Immunology
|February 12, 2025
Summary
Neutrophils and their role in multiple sclerosis (MS) are increasingly recognized. Neutrophil extracellular traps (NETs) may significantly contribute to MS pathogenesis, offering potential therapeutic targets.
Area of Science:
- Immunology
- Neuroscience
- Pathology
Background:
- Multiple sclerosis (MS) is a chronic autoimmune disease causing demyelination and neuronal damage.
- Neutrophils, inflammatory cells, are increasingly implicated in MS pathogenesis.
- Neutrophil extracellular traps (NETs) are a key mechanism under investigation.
Purpose of the Study:
- To review the clinical relevance of neutrophils in MS and EAE models.
- To explore the role of NETs in MS pathogenesis.
- To analyze NETs as potential therapeutic targets for MS.
Main Methods:
- Literature review focusing on neutrophils and NETs in MS and EAE.
- Analysis of proposed mechanisms of NET involvement in MS.
- Evaluation of NETs' protective and detrimental effects in MS.
Main Results:
- Neutrophils play significant roles in MS and EAE.
- NET formation is a potential contributor to MS pathogenesis.
- NETs present both detrimental and protective aspects in MS.
Conclusions:
- NETs are a promising area for MS research and therapeutic intervention.
- Further research is needed to fully understand NET formation and clearance in MS treatment.
Keywords:
experimental autoimmune encephalomyelitismultiple sclerosisneutrophil extracellular trapsneutrophilstherapeutic target
