Acute Myocardial Infarction With Nonobstructive Coronary Arteries Across Endocrine Disorders: A Case Series

Area of Science:

• Endocrinology
• Cardiology
• Internal Medicine

Background:

• The intersection of endocrine disorders and cardiovascular health is critical.
• Myocardial infarction without obstructive coronary artery disease (MINOCA) presents a diagnostic challenge.
• Endocrine diseases are an underrecognized cause of MINOCA.

Observation:

• A case series involving three patients with distinct endocrine diseases presenting with MINOCA.
• Diagnoses included Cushing's disease (pituitary microadenoma), adrenal pheochromocytoma, and primary hyperaldosteronism (unilateral adrenal hyperplasia).

Findings:

• All patients showed significant improvement after conservative management of their endocrine and cardiovascular conditions.
• Classical endocrine disorders can manifest as MINOCA, with the underlying cause frequently missed.

Implications:

• Highlights the importance of considering endocrine etiologies in MINOCA patients, especially those lacking traditional cardiovascular risk factors.
• Suggests that a hormonal workup is essential for diagnosing the underlying cause of MINOCA in select patients.
• Emphasizes the need for integrated endocrine and cardiology care for comprehensive patient management.