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Anatomy of the Brain: Ventricles

Anatomy of the Brain: Ventricles

There are hollow fluid-filled cavities known as ventricles deep inside the human brain. There are two lateral ventricles, one in each cerebral hemisphere, and each has three different projections — the anterior, inferior, and posterior horns visible from the lateral side. A thin membrane called the septum pellucidum separates the two lateral ventricles. The slender third ventricle in the diencephalon is connected to each lateral ventricle via a channel called the interventricular foramen.

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Related Experiment Video

Updated: May 28, 2025

The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow

The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow

Published on: May 6, 2010

The subventricular zone structure, function and implications for neurological disease.

Kaishu Li^1,2, Yin Zheng^1,2, Shubing Cai^1,2

¹Department of Neurosurgery, The Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China.

Genes & Diseases

|February 12, 2025

Summary

This summary is machine-generated.

The subventricular zone (SVZ) contains stem cells vital for brain repair. Understanding SVZ mechanisms is key for treating neurological diseases and advancing neural stem cell therapy.

Keywords:

Glioblastoma multiforme Neural injury repair Neural stem cells Neurodegenerative Subventricular zone

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Last Updated: May 28, 2025

The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow

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Published on: May 6, 2010

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse

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Published on: May 19, 2015

Cryo-section Dissection of the Adult Subependymal Zone for Accurate and Deep Quantitative Proteome Analysis

Cryo-section Dissection of the Adult Subependymal Zone for Accurate and Deep Quantitative Proteome Analysis

Published on: October 7, 2021

Area of Science:

Neuroscience
Stem Cell Biology

Background:

The subventricular zone (SVZ) is a niche containing neural stem cells and progenitor cells.
SVZ cells generate diverse neural and glial cells, crucial for brain function.
These cells are implicated in neurological diseases such as neurodegeneration, injury, and glioblastoma.

Purpose of the Study:

To review the anatomy, physiology, and disease relevance of the SVZ.
To highlight the significance of SVZ research for neural stem cell therapy.
To identify challenges and future directions in SVZ research and therapeutic applications.

Main Methods:

Literature review of existing research on the subventricular zone.
Synthesis of findings on SVZ cell behavior and its role in neurological disorders.
Analysis of current therapeutic strategies and challenges related to SVZ.

Main Results:

SVZ cells are critical for neurogenesis and brain repair.
Dysregulation of SVZ cells contributes to various neurological conditions.
Significant challenges persist in controlling SVZ cell proliferation, differentiation, migration, and immune integration for therapeutic purposes.

Conclusions:

Continued investigation into SVZ mechanisms is essential for developing effective neural stem cell therapies.
Understanding the SVZ offers potential for novel treatments for brain injuries and degenerative diseases.
Addressing current research challenges will pave the way for advanced therapeutic interventions.