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Hallucinogen-Persisting Perception Disorder in a 16-Year-Old Adolescent
Anna Mori-Kreiner1, Arpit Aggarwal2, Meelie Bordoloi3
1Mori-Kreiner, University of Missouri School of Medicine, Columbia, Missouri, United States.
Psychopharmacology Bulletin
|February 12, 2025
Summary
Hallucinogen-persisting Perception Disorder (HPPD) is a rare condition. Aripiprazole showed gradual improvement in an adolescent patient with HPPD, though diagnosis was complicated by polysubstance use.
Area of Science:
- Neuroscience
- Psychiatry
- Pharmacology
Background:
- Hallucinogen-persisting Perception Disorder (HPPD) is characterized by persistent perceptual disturbances after hallucinogen use.
- Documented cases of HPPD in pediatric populations are scarce, making this case report significant.
Observation:
- A 16-year-old male with a history of major depressive disorder and polysubstance use presented with auditory and visual hallucinations.
- Symptoms included auditory hallucinations and heightened hearing sensitivity, occurring between substance use episodes.
Findings:
- Aripiprazole was administered at 5 mg for HPPD treatment, resulting in gradual symptom improvement.
- Literature review indicated limited efficacy of second-generation antipsychotics for HPPD, with aripiprazole being a notable exception.
Implications:
- This case highlights the presentation and potential efficacy of aripiprazole in treating adolescent HPPD.
- Differentiating HPPD from other substance-induced psychotic disorders is crucial in adolescent patients with polysubstance use history.
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