Raised Creatine Kinase with Numerous Antipsychotics Responded to Clozapine

There is much uncertainty on continuing antipsychotics where a patient has an asymptomatic rise in creatine kinase. This case report describes a patient in his late 20s and early 30s with an established diagnosis of schizophrenia. He experienced multiple asymptomatic rises in creatine kinase (CK) when treated with numerous antipsychotics, which led to them being discontinued. Eventually, successful treatment was undertaken when clozapine was trialled. This led to improved quality of life scores when objectively measured, as well as good tolerance with no physical health sequelae. In conclusion, we recommend that clozapine is considered when other antipsychotic medications lead to elevated CK levels or neuroleptic malignant syndrome.