Related Experiment Video
Updated: May 28, 2025

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine
Published on: January 30, 2020
Double Sequential Defibrillation: An Update of Contemporary Defibrillation Strategies for Pulseless Ventricular
1Cardiology, Adventist Health System, Rockville, USA.
Abstract:
In a clinical trial, the role of double sequential external defibrillation (DSED) in treating refractory ventricular fibrillation (VF) was evaluated. Many Americans suffer from sudden cardiac arrest daily, and resuscitation rates are low especially in patients with refractory ventricular tachycardia (VT)/fibrillation. This trial was a prehospital resuscitation trial exploring methods to improve meaningful survival in this difficult patient cohort. I applaud the efforts of this trial, along with all of those involved in research and education, in trying to improve outcomes by improving recognition and bystander CPR, reducing delays in EMS activation, initiating CPR and the first delivery of a defibrillation shock, and adjusting pad placement to more successfully defibrillate the patient. In this editorial, I discuss in detail the outcomes of this landmark clinical trial, along with supplemental information submitted by the primary authors. Also, I review the updated defibrillation outcomes by defibrillator pad placement and defibrillation vectors. Finally, I give my recommendation to not include DSED in contemporary resuscitation guidelines and my rationale and justification for my recommendation.
More Related Videos
09:47A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique
Published on: April 26, 2015
06:57Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction
Published on: January 31, 2019
Related Concept Videos
Disturbances in Heart Rhythm
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
Pulse rhythm
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers
Antiarrhythmic Drugs: Class IV Agents as Calcium Channel Blockers
Verapamil, a calcium channel blocker, inhibits calcium movement across myocardial cell membranes and vascular smooth muscle. This results in the dilation of coronary and...
Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers
Cardiac Action Potential
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials