Related Experiment Video

Updated: May 28, 2025

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

16.3K

Depressive Symptoms and Left Ventricular Diastolic Dysfunction Among Men and Women with HIV

Claudia Martinez1, Nel Jason Haw2, Violeta J Rodriguez3

  • 1University of Miami Miller School of Medicine, Florida, USA.

European Medical Journal. Cardiology
|February 12, 2025
PubMed

Insights

Depressive symptoms were not significantly linked to left ventricular diastolic dysfunction (LVDD) in adults with or without HIV. Further research is needed to understand this relationship in the context of modern HIV treatment.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Psychiatry

Background:

  • Depressive symptoms are common in adults with HIV and linked to cardiovascular disease.
  • Left ventricular diastolic dysfunction (LVDD) is a cardiac condition that can affect heart function.

Purpose of the Study:

  • To investigate the association between depressive symptoms and LVDD in men and women living with and without HIV.

Main Methods:

  • Cross-sectional analysis of data from the Multicenter AIDS Cohort Study (MACS) and Women's Interagency HIV Study (WIHS).
  • Participants had controlled HIV (CD4 >350, viral load <499).
  • LVDD was assessed using the Characterizing Heart Function on Antiretroviral Therapy (CHART) criteria; statistical models adjusted for multiple factors.

Main Results:

  • The study included 874 men and 1,191 women; 22.5% had LVDD and 30.8% reported depressive symptoms.
  • Depressive symptoms were not significantly associated with LVDD overall.
  • Associations between individual LVDD components and depression were small to medium but generally not significant.

Conclusions:

  • The study did not find a significant association between depressive symptoms and LVDD in people with HIV on combination antiretroviral therapy.
  • Further research is warranted to explore this relationship in the current treatment era.
Abstract

Keywords:
Depressive symptomsHIVleft ventricular diastolic dysfunction

More Related Videos

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

592
Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty07:27

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Published on: October 6, 2016

10.1K

Related Concept Videos

Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
37
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
40
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.5K
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
25
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.3K
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
307