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YAP/TAZ-associated cell signaling - at the crossroads of cancer and neurodevelopmental disorders.

Aderonke O Ajongbolo^1,2, Sigrid A Langhans¹

¹Division of Neurology and Nemours Biomedical Research, Nemours Children's Health, Wilmington, DE, United States.

Frontiers in Cell and Developmental Biology

|February 12, 2025

Summary

Yes-associated protein/paralog transcriptional co-activator with PDZ-binding domain (YAP/TAZ) are key Hippo pathway effectors. YAP/TAZ dysregulation links brain development, cancer, and neurodevelopmental disorders.

Keywords:

Hippo YAP/TAZ signaling brain cancer microenvironment neurodevelopmental disorder

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Published on: December 20, 2021

Area of Science:

Cell Biology
Molecular Biology
Developmental Biology

Background:

Yes-associated protein/paralog transcriptional co-activator with PDZ-binding domain (YAP/TAZ) are downstream effectors of the Hippo signaling pathway.
YAP/TAZ regulate crucial cellular outcomes like differentiation, proliferation, and apoptosis.
Non-canonical pathways, including growth factor signaling and mechanical cues, also influence YAP/TAZ activity.

Purpose of the Study:

To review the multifaceted role of YAP/TAZ signaling.
To explore YAP/TAZ involvement in brain development, cancer, and neurodevelopmental disorders.
To highlight the interconnectedness of YAP/TAZ in these conditions.

Main Methods:

Literature review of YAP/TAZ signaling pathways.
Analysis of YAP/TAZ roles in development and disease.
Focus on non-canonical regulation and Hippo pathway interactions.

Main Results:

YAP/TAZ are central to a complex signaling network regulating development and regeneration.
Dysregulation of YAP/TAZ is implicated in various cancers and neurodevelopmental disorders.
Parallels exist between cancer and neurodevelopmental disorders concerning YAP/TAZ signaling.

Conclusions:

YAP/TAZ play a critical role in both normal development and disease pathogenesis.
Understanding YAP/TAZ signaling is crucial for addressing complex diseases.
Further research into YAP/TAZ interconnections can reveal therapeutic strategies.