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An Insight to Hyperhomocysteinaemia in CKD Patients of a Tertiary Care Hospital, Karachi

Nadia Yaqub1, Adnan Mustafa Zubairi, Fatima Kanani

  • 1Department of Chemical Pathology, Indus Hospital and Health Network, Karachi, Pakistan.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|February 12, 2025
PubMed

Insights

Hyperhomocysteinaemia (HHcy) is highly prevalent in chronic kidney disease (CKD) patients, particularly in advanced stages. While HHcy indicates disease progression, this study found no significant association with estimated glomerular filtration rate (eGFR) stages.

Area of Science:

  • Nephrology
  • Clinical Chemistry
  • Public Health

Background:

  • Hyperhomocysteinaemia (HHcy) is a risk factor for cardiovascular disease and mortality.
  • Chronic kidney disease (CKD) affects homocysteine metabolism.
  • Understanding HHcy prevalence in CKD is crucial for patient management.

Purpose of the Study:

  • To determine the frequency of HHcy in CKD patients across different stages.
  • To investigate the association between HHcy and CKD severity.

Main Methods:

  • A cross-sectional study involving 100 CKD patients.
  • Estimated glomerular filtration rate (eGFR) calculated using the CKD-EPI calculator for staging.
  • Plasma homocysteine (Hcy) and serum creatinine levels measured.
  • Statistical analysis including Chi-square test performed.

Main Results:

  • 79% of CKD patients exhibited HHcy.
  • HHcy prevalence increased with CKD stage, highest in stage 5 (41.8%).
  • No significant association was found between Hcy concentration and eGFR stages.

Conclusions:

  • HHcy is highly prevalent in CKD patients, especially in later stages.
  • Hcy may serve as a predictor of CKD progression.
  • Further research and timely interventions are needed to mitigate adverse outcomes.
Abstract

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