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Updated: May 28, 2025

Diagonal Method to Measure Synergy Among Any Number of Drugs
Published on: June 21, 2018
Determining the Interaction in a Drug Combination using the Dose-based or Effect-based Method
Tinghe Yu1, Tianyan Yu2, Xinya Li1
1Laboratory of Obstetrics and Gynecology, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
None:
The interaction in a drug combination can be assessed using either the Chou's or Jin's method. The combination index in the former (i.e., CI-C) is calculated based on doses, while the latter (i.e., CI-J) is based on effects. This perspective demonstrates a consistency between 1/CI-C and CI-J when applied to both released and simulated data. Thus, 1/CI-C and CI-J are functionally equivalent for evaluating the drug interaction. Combining these two indices is preferred: a consistency shows a reliable verdict, and an inconsistency indicates a requirement for further analyses. However, it has been observed that evaluating released data raises certain concerns.
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