Related Experiment Video
Updated: May 28, 2025

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
The role of CD57+γδ T cells in the immune pathogenesis of patients with sepsis
Liman Li1,2,3, Nenggang Jiang1,2,3, Yongmei Jin1,2,3
1Department of Laboratory Medicine, West China Hospital of Sichuan University, 37 Guoxue Alley, Wuhou District, Chengdu, Sichuan Province, Chengdu, Sichuan Province 610041, China.
Abstract:
The immune responses are dysregulated during sepsis. This study aimed to investigate the role of CD57+γδ T cells in the immune pathogenesis of patients with sepsis. We characterized the transcriptomic profile of peripheral γδ T cells from patients with sepsis using smart RNA sequencing. Additionally, we assessed the ratios and immune functional signatures of CD57+γδ T cells in sepsis through flow cytometry. The cytotoxic capacity of the CD57+γδ T-cell subset was also validated in vitro. Our findings revealed a reduction in the proportion of peripheral CD57+γδ T cells in patients with sepsis, which was correlated with clinical outcomes. Compared with CD57-γδ T cells, CD57+γδ T cells exhibited a markedly altered immunophenotype, including decreased expression of costimulatory molecules and increased expression of proinflammatory factors and cytotoxic granules. Our study proposed a potential role of CD57 in sepsis and its utility as a novel biomarker for patients with sepsis.
Related Concept Videos
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Defense Against Bacterial Pathogens
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Cell-mediated Immune Responses

