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Updated: May 28, 2025
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Published on: March 28, 2025
Melatonin alleviates oral epithelial cell inflammation via Keap1/Nrf2 signaling
Nan Zhang1, Wenjing Wang2, Rongxia Zhang1
1Department of Stomatology, Second Hospital of Shijiazhuang, Shijiazhuang, Hebei, China.
Background:
Oral mucosal diseases manifest primarily as inflammatory conditions. These diseases affect approximately half a billion people worldwide.
Objective:
Novel and effective strategies for treating inflammatory diseases of the oral mucosa have great potential for improving patient outcomes, and warrant study.
Methods:
The impact of melatonin on inflammation was investigated using RAW264.7 macrophages and HOEC and HSC-3 oral epithelial cells.
Results:
Melatonin decreased macrophage-induced inflammation by acting through the melatonin receptor MTNR1A. Additionally, melatonin mitigated macrophage-induced inflammation in oral epithelial cells. Importantly, the results demonstrated that the effects of melatonin on oral epithelial inflammation were mediated through the KEAP1/Nrf2 signaling pathway.
Conclusion:
These findings will contribute to the development of innovative therapies for inflammatory conditions affecting the oral epithelium.
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