Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Physiological Foundation of Stress01:24

Physiological Foundation of Stress

43
Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
43
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

59.0K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
59.0K
Regulation of Food Intake01:30

Regulation of Food Intake

179
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
179
Introduction to Stress and Lifestyle01:27

Introduction to Stress and Lifestyle

69
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
69
Psychological Responses to Stress01:20

Psychological Responses to Stress

40
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
40
The Sympathetic Nervous System01:25

The Sympathetic Nervous System

94.3K
Overview
94.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Celebrating 30 years of the discovery of leptin: a revolutionary shift in understanding obesity and metabolism.

American journal of physiology. Endocrinology and metabolism·2025
Same author

A limbic circuit selectively links active escape to food suppression.

eLife·2020
Same author

A 2x folic acid treatment affects epigenetics and dendritic spine densities in SHSY5Y cells.

Biochemistry and biophysics reports·2019
Same author

Cross Talk Between Brain Innate Immunity and Serotonin Signaling Underlies Depressive-Like Behavior Induced by Alzheimer's Amyloid-β Oligomers in Mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2016

Related Experiment Video

Updated: May 28, 2025

Control of Eating Behavior Using a Novel Feedback System
04:48

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

10.9K

Hunger Games: A Modern Battle Between Stress and Appetite.

Whitnei Smith1, Estefania P Azevedo1

  • 1Laboratory of Neurobiology of Behavior, Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina, USA.

Journal of Neurochemistry
|February 12, 2025
PubMed
Summary

Chronic stress significantly impacts eating disorders (EDs) by disrupting neural circuits. Understanding the interplay between genetics, environment, and the gut microbiome is crucial for developing effective treatments for EDs.

Keywords:
circuitseating disordersfeedingstress

More Related Videos

Hyponeophagia: A Measure of Anxiety in the Mouse
05:52

Hyponeophagia: A Measure of Anxiety in the Mouse

Published on: May 17, 2011

21.9K
Errors as a Means of Reducing Impulsive Food Choice
07:07

Errors as a Means of Reducing Impulsive Food Choice

Published on: June 5, 2016

8.6K

Related Experiment Videos

Last Updated: May 28, 2025

Control of Eating Behavior Using a Novel Feedback System
04:48

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

10.9K
Hyponeophagia: A Measure of Anxiety in the Mouse
05:52

Hyponeophagia: A Measure of Anxiety in the Mouse

Published on: May 17, 2011

21.9K
Errors as a Means of Reducing Impulsive Food Choice
07:07

Errors as a Means of Reducing Impulsive Food Choice

Published on: June 5, 2016

8.6K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Stress is a pervasive modern challenge impacting feeding behaviors and eating disorders (EDs).
  • The hypothalamic-pituitary-adrenal (HPA) axis and interconnected brain regions (hypothalamus, hippocampus, lateral septum) are key in integrating stress and feeding signals.
  • Genetic predispositions and environmental factors contribute to ED vulnerability.

Purpose of the Study:

  • To review the mechanisms linking stress and eating disorders (EDs).
  • To highlight animal models and novel cellular/molecular mechanisms in ED research.
  • To discuss the role of the gut microbiome and identify research gaps.

Main Methods:

  • Review of existing literature on stress, neural circuits, and eating disorders.
  • Analysis of rodent studies investigating stress-feeding interactions.
  • Discussion of emerging research areas like gut microbiome and advanced imaging.

Main Results:

  • Stress dysregulates neural circuits and brain regions involved in feeding and emotional regulation.
  • Novel cellular and molecular mechanisms integrating stress and feeding signals are being discovered.
  • The gut microbiome is an emerging factor in ED pathogenesis.

Conclusions:

  • Further research is needed to understand stressor impact on neural circuits and neuropeptide roles (CRH, oxytocin, GLP-1) in EDs.
  • Advanced tools like single-cell sequencing and human imaging can reveal brain changes in ED patients.
  • Integrating basic and clinical research is essential for personalized, mechanism-based ED treatments.