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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Halogenated Donor-Acceptor Cyclopropanes as Donor-Acceptor Cyclopropene Surrogates

Gwyndaf A Oliver1, Simon Kolb1, Malini George1

  • 1Albert-Ludwigs-Universität Freiburg, Institute of Organic Chemistry, Albertstr. 21, 79104, Freiburg (im Breisgau), Germany.

Angewandte Chemie (International Ed. in English)
|February 12, 2025
PubMed
Summary

Halogenated donor-acceptor cyclopropanes (HDACs) serve as effective cyclopropene surrogates in (3+2)-cycloaddition reactions. These reactions yield unsaturated five-membered rings, demonstrating broad applicability with various 2π-components and thioketones.

Keywords:
CycloadditionCyclopropanesCyclopropenesDonor–acceptor systemsLewis acids

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