Breaking the Limitation of Laminar Flow in Thrombolytic Therapy with Reconfigurable Vortex-Like Nanobot Swarms

Laminar blood flow represents the normal physiological state of blood circulation, but it also acts as a natural physiological barrier for the effective diffusion of drugs to the lesion site. Here, we report a bioinspired strategy in which reconfigurable vortex-like swarms of magnetic swimming nanobots actively disrupt the laminar flow to deliver drugs in a manner similar to how bacteria seek food. The drug was released from the cavity of biodegradable, submicron pentosan flask-like nanobots, aggregates as the dynamic rotating drug fluid under a rotating magnetic field. The vortex-like nanobot swarm successfully overcame the laminar barrier near the thrombus in a rat inferior vena cava stenosis thrombosis model, which was observed by ultrasound blood flow imaging. Furthermore, the clinical feasibility of nanobots swarm for enhancing thrombolytic efficacy through drug aggregation after breaking the laminar flow was further confirmed in a rat deep vein thrombosis model. This bionic active targeting approach overcomes the laminar flow barrier and restricts the release of drugs by the swarm-induced vortex fluid to facilitate targeted drug delivery, which is expected to be an innovative method to enhance drug delivery efficiency.