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Tuning Atomically Dispersed Metal Sites in Nanozymes for Sensing Applications
Mingwang Liu1, Weiqing Xu1, Yinjun Tang1
1State Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, P. R. China.
Angewandte Chemie (International Ed. in English)
|February 12, 2025
Summary
Atomically dispersed nanozymes (ADzymes) offer superior catalytic activity for sensing applications. This review highlights their properties, regulation strategies, and diverse applications in advanced biosensing technologies.
Area of Science:
- Materials Science
- Nanotechnology
- Analytical Chemistry
Background:
- Atomically dispersed nanozymes (ADzymes), particularly single-atom nanozymes, mimic natural enzyme active sites.
- ADzymes maximize catalytic site exposure and exhibit enhanced catalytic activity for complex reactions.
- Their unique properties make them highly promising for sensing and biosensing applications.
Purpose of the Study:
- To review the classification, properties, and regulation strategies of ADzymes.
- To highlight recent advances in ADzyme applications across various sensing platforms.
- To discuss signal amplification mechanisms and future perspectives for ADzyme development.
Main Methods:
- Systematic review of ADzyme properties and regulation strategies (central metal, coordination environment).
- Summarization of ADzyme applications in colorimetric, fluorescent, electrochemical, and luminescence-based sensing.
- Analysis of signal amplification mechanisms for enhanced detection sensitivity and selectivity.
Main Results:
- ADzymes demonstrate superior catalytic activity, specificity, and multifunctionality through tailored design.
- Significant progress has been made in applying ADzymes to diverse sensing fields.
- Effective signal amplification strategies utilizing ADzymes enable highly sensitive and selective target detection.
Conclusions:
- ADzymes offer exceptional potential for sensitive, selective, and accurate detection of various targets.
- Further research into advanced ADzyme design and application is warranted.
- Addressing current challenges will pave the way for next-generation ADzyme-based sensing technologies.
