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Related Experiment Video

Updated: May 28, 2025

Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications

Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications

Published on: November 10, 2017

Molecular Upconversion Nanoparticles for Live-Cell Imaging.

Lucie Haye^1,2, Federico Pini^3,4,5, Lohona Kevin Soro⁶

¹Université de Strasbourg, CNRS, Laboratoire de Bioimagerie et Pathologies UMR 7021, Strasbourg 67000, France.

|February 12, 2025

Summary

This summary is machine-generated.

Researchers developed bright molecular upconversion nanoparticles (UCMol-NPs) for bioimaging. Encapsulating upconversion molecules in polymer nanoparticles achieved brightness comparable to inorganic nanoparticles, enabling live-cell imaging.

Keywords:

UCNPs imaging modeling nanomaterials upconverting complexes

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Last Updated: May 28, 2025

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Published on: August 30, 2017

Area of Science:

Materials Science
Biotechnology
Nanotechnology

Background:

Precise molecular control is crucial for advanced upconversion materials in autofluorescence-free deep tissue imaging.
Current upconversion molecules are significantly dimmer than inorganic nanoparticles in aqueous environments, limiting bioimaging applications.

Purpose of the Study:

To combine molecular precision with nanomaterial brightness for novel upconversion materials.
To develop hybrid nanomaterials for enhanced bioimaging capabilities.

Main Methods:

Encapsulation of approximately 1,900 upconversion molecules into sub-40 nm polymer nanoparticles.
Fabrication, characterization, and modeling of molecular upconversion nanoparticles (UCMol-NPs) with varying sizes and molecular loadings.

Main Results:

Developed hybrid UCMol-NPs with brightness nearly matching widely used inorganic upconversion nanoparticles.
Demonstrated successful live-cell imaging using UCMol-NPs, validating their potential for biological applications.
Identified pathways for significant brightness enhancement in UCMol-NPs through fabrication and modeling.

Conclusions:

Molecular precision and nanomaterial brightness can be synergistically achieved in hybrid UCMol-NPs.
UCMol-NPs represent a significant advancement for upconversion materials, moving towards practical bioimaging applications.
Further optimization of UCMol-NPs holds promise for surpassing current inorganic nanoparticle limitations and enabling clinical translation.