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Radiomics for differentiating radiation-induced brain injury from recurrence in gliomas: systematic review,
Burak Kocak1, Ismail Mese2, Ece Ates Kus3
1Department of Radiology, University of Health Sciences, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey. drburakkocak@gmail.com.
European Radiology
|February 12, 2025
Summary
Radiomics shows promise in differentiating radiation-induced brain injury from glioma recurrence, but results must be cautiously interpreted due to quality concerns and publication bias in current literature.
Area of Science:
- Neuro-oncology
- Medical Imaging
- Radiomics
Background:
- Distinguishing radiation-induced brain injury from glioma recurrence is critical for effective patient management.
- Radiomics offers a non-invasive approach to analyze medical images for diagnostic purposes.
Purpose of the Study:
- To systematically evaluate the quality and findings of radiomics studies differentiating radiation-induced brain injury from glioma recurrence.
- To assess the reliability of radiomics-specific quality scoring tools.
Main Methods:
- Systematic literature search on PubMed and Web of Science.
- Quality assessment using METhodological RadiomICs Score (METRICS) and Radiomics Quality Score (RQS).
- Meta-analysis, meta-regression, and subgroup analysis of eligible studies.
Main Results:
- Twenty-seven papers were included; meta-analysis of 11 studies showed an AUC of 0.832.
- Significant heterogeneity (I²=91%) and publication bias towards positive findings were observed.
- Methodological quality scores (METRICS, RQS) indicated areas for improvement, with moderate inter-rater agreement.
Conclusions:
- Radiomics demonstrates potential for differentiating radiation-induced brain injury from glioma recurrence.
- Caution is advised when interpreting results due to heterogeneity, publication bias, and methodological quality concerns.
- Further high-quality, validated studies are needed to enhance clinical translation of radiomics.
