Harnessing Plant-Derived Terpenoids for Novel Approaches in Combating Bacterial and Parasite Infections in Veterinary...

The rising resistance to conventional antimicrobial therapies in veterinary contexts poses a formidable challenge. While various innovative treatment strategies for pathogenic infections have emerged, their success still needs to be improved, warranting continued research. Recent investigations into natural products as potential sources for biologically active therapeutics have gained traction. Phytochemicals present a promising alternative in combating a spectrum of pathogens, including bacteria, fungi and parasites. One such class of phytochemicals with mounting potential is the structurally diverse terpenes. These chemicals contribute to plants' characteristic odour and medicinal effects and have been widely investigated in the scientific literature for their exceptional antibacterial activity. Their efficacy is demonstrated through diverse mechanisms, encompassing damage to bacterial membranes, suppression of virulence factors, and interference with enzymes, toxins, and biofilm formation. This review comprehensively examines terpenes' in vitro and in vivo activity and their derivatives against pathogens, elucidating their potential against antimicrobial resistance (AMR) and the underlying mechanisms specific to each terpene class. The findings underscore the burgeoning potential of terpene therapy as a viable alternative or supplementary approach to conventional antibiotics in addressing bacterial and parasitic infections in livestock and companion animals.