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Updated: May 28, 2025
Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases
Published on: March 11, 2016
Classification of fundus autofluorescence images based on macular function in retinitis pigmentosa using
Taro Kominami1, Shinji Ueno2,3, Junya Ota2
1Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsuruma- cho, Showa-ku, Nagoya, 466-8550, Japan. taro.kominami@gmail.com.
Purpose:
To determine whether convolutional neural networks (CNN) can classify the severity of central vision loss using fundus autofluorescence (FAF) images and color fundus images of retinitis pigmentosa (RP), and to evaluate the utility of those images for severity classification.
Study Design:
Retrospective observational study.
Methods:
Medical charts of patients with RP who visited Nagoya University Hospital were reviewed. Eyes with atypical RP or previous surgery were excluded. The mild group was comprised of patients with a mean deviation value of > - 10 decibels, and the severe group of < - 20 decibels, in the Humphrey field analyzer 10-2 program. CNN models were created by transfer learning of VGG16 pretrained with ImageNet to classify patients as either mild or severe, using FAF images or color fundus images.
Results:
Overall, 165 patients were included in this study; 80 patients were classified into the severe and 85 into the mild group. The test data comprised 40 patients in each group, and the images of the remaining patients were used as training data, with data augmentation by rotation and flipping. The highest accuracies of the CNN models when using color fundus and FAF images were 63.75% and 87.50%, respectively.
Conclusion:
Using FAF images may enable the accurate assessment of central vision function in RP. FAF images may include more parameters than color fundus images that can evaluate central visual function.
