Related Experiment Video
Updated: Aug 15, 2026
Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining
Published on: December 23, 2016
Retroperitoneal fibromatosis and acquired immunodeficiency syndrome in macaques. Pathologic observations and
Abstract:
A peculiar fibroproliferative syndrome called retroperitoneal fibromatosis (RF) has been observed in Macaca nemestrina, Macaca mulatta, Macaca fascicularis, and Macaca fuscata at the Washington Regional Primate Research Center. RF is characterized by the aggressive proliferation of highly vascular fibrous tissue subjacent to the peritoneum covering the ileocecal junction and associated mesenteric lymph nodes. In the early, proliferative phase of the disease, most of the fibroblastlike cells contain Factor VIII-related antigen. Two syndromes have been recognized: localized, in which fibroproliferative lesions occur only in solitary nodules; and progressive, in which fibromatosis occurs throughout the abdominal cavity. RF-affected monkeys often develop a simian acquired immunodeficiency syndrome (SAIDS) with severe thymic and lymphoid atrophy, chronic enterocolitis, and wasting. Experimental intraperitoneal inoculation with suspensions of RF tissue in two separate experiments resulted in the development of SAIDS in 5 of 16 and RF-SAIDS in 3 of 16 macaques. RF associated with SAIDS appears to be an excellent model for the Kaposi's sarcoma associated with AIDS.
Insights
Retroperitoneal fibromatosis (RF) in macaques can progress to simian acquired immunodeficiency syndrome (SAIDS). This primate model offers insights into Kaposi
Area of Science:
- Veterinary Pathology
- Primate Models
- Fibroproliferative Diseases
Background:
- Retroperitoneal fibromatosis (RF) is a rare fibroproliferative disorder observed in several macaque species.
- RF involves aggressive fibrous tissue proliferation near the ileocecal junction and mesenteric lymph nodes.
- Factor VIII-related antigen is present in fibroblast-like cells during the early proliferative phase of RF.
Purpose of the Study:
- To characterize retroperitoneal fibromatosis (RF) in macaques.
- To investigate the association between RF and simian acquired immunodeficiency syndrome (SAIDS).
- To evaluate RF-associated SAIDS as a model for human Kaposi's sarcoma.
Main Methods:
- Observation and characterization of naturally occurring RF in macaques.
- Experimental induction of SAIDS and RF-SAIDS through intraperitoneal inoculation of RF tissue.
- Clinical and pathological assessment of affected macaques.
Main Results:
- Two forms of RF were identified: localized and progressive.
- Macaques with RF frequently developed SAIDS, characterized by lymphoid atrophy, enterocolitis, and wasting.
- Experimental inoculation led to SAIDS in 5/16 and RF-SAIDS in 3/16 macaques.
Conclusions:
- Retroperitoneal fibromatosis in macaques is associated with simian acquired immunodeficiency syndrome (SAIDS).
- The RF-SAIDS complex in macaques serves as a valuable model for studying Kaposi's sarcoma in acquired immunodeficiency syndrome (AIDS).
- Further research into this primate model can elucidate mechanisms relevant to human diseases.
More Related Videos
11:06Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques
Published on: May 2, 2017
07:21Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment
Published on: June 23, 2019