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Hepatoprotective Effect of a Kalanchoe pinnata-Based Beverage Against Carbon Tetrachloride- and Gentamicin-Induced Hepatotoxicity in Wistar Rats

  • 0Institute of Food Science and Technology, Faculty of Food Health Science and Technology, Khwaja Fareed University of Engineering and Information Technology, Rahim Yar Khan, Pakistan.
Journal of the American Nutrition Association +

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February 12, 2025

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February 12, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Kalanchoe pinnata shows promise in protecting the liver from damage. This study found that a Kalanchoe pinnata beverage reduced liver enzymes and improved protein levels in rats with induced liver injury.

Area Of Science

  • Phytochemistry
  • Hepatoprotective Agents
  • Toxicology

Background

  • Chronic liver diseases cause millions of deaths yearly.
  • Investigating natural remedies for liver protection is crucial.
  • Kalanchoe pinnata is explored for its potential health benefits.

Purpose Of The Study

  • To evaluate the prophylactic effects of Kalanchoe pinnata against induced liver stress.
  • To assess the antioxidant capacity of Kalanchoe pinnata extracts.
  • To determine the impact of a Kalanchoe pinnata beverage on liver function markers.

Main Methods

  • Kalanchoe pinnata leaves were extracted using three methods: conventional solvent, supercritical fluid, and microwave-assisted extraction.
  • Antioxidant activity was assessed using DPPH, FRAP, and ABTS assays.
  • Hepatotoxicity was induced in male Wistar rats using carbon tetrachloride (CCl4) and gentamicin.

Main Results

  • Supercritical fluid extract yielded the highest antioxidant activity.
  • Kalanchoe pinnata beverage administration reduced elevated serum liver enzymes (AST, ALP, ALT) and bilirubin levels.
  • Treatment with the beverage improved serum total protein, albumin, and globulin levels in rats.

Conclusions

  • Kalanchoe pinnata possesses significant antioxidant properties.
  • The Kalanchoe pinnata beverage demonstrated a protective effect against CCl4- and gentamicin-induced hepatotoxicity.
  • Findings support the therapeutic potential of Kalanchoe pinnata for liver disease management.

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