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Treatment Resistant Cancers02:56

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting
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Papillary Fibroelastomas: 16-Year Single-Center Experience.

Strahinja Mrvic1,2, Ranko Zdravkovic1,3, Andrej Preveden1,3

  • 1Clinic of Cardiovascular Surgery, Institute of Cardiovascular Diseases of Vojvodina, Sremska Kamenica, Serbia.

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Papillary fibroelastomas are rare cardiac tumors, often asymptomatic. Complete surgical resection offers a safe and effective treatment with a good prognosis for these benign tumors.

Keywords:
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Area of Science:

  • Cardiovascular Pathology
  • Cardiac Oncology
  • Surgical Oncology

Background:

  • Papillary fibroelastomas are rare, primary benign cardiac tumors.
  • Most patients remain asymptomatic, but complications include embolic events, syncope, arrhythmias, and sudden death.
  • This study details a series of papillary fibroelastomas diagnosed and treated at a single institution.

Purpose of the Study:

  • To report on the clinical characteristics and outcomes of patients with cardiac papillary fibroelastomas.
  • To analyze demographic, tumor, and treatment data for this rare condition.

Main Methods:

  • Retrospective review of medical records from 2007-2022.
  • Inclusion criteria: surgically treated and histologically confirmed cardiac papillary fibroelastomas.
  • Analysis of clinical, demographic, echocardiographic, and treatment data.

Main Results:

  • Twelve cases of papillary fibroelastomas were documented over 16 years.
  • The majority of patients were female (83.3%) with an average age of 59.0 years.
  • The aortic valve was the most common site (50%), with tumors averaging 1.2 cm; all patients underwent successful complete resection.

Conclusions:

  • Papillary fibroelastomas are typically small, solitary tumors.
  • Complete surgical resection is a safe, effective, and definitive treatment with a favorable prognosis.