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Global burden of HBV-related liver disease: Primary liver cancer due to chronic HBV infection increased in over

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Global trends show decreasing HBV-related liver disease, but primary liver cancer (PLC) incidence is rising in many countries. Strengthened Hepatitis B virus (HBV) treatment is crucial to combat rising HBV-related PLC.

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Area of Science:

  • Hepatology
  • Global Health
  • Epidemiology

Background:

  • Hepatitis B virus (HBV)-related liver disease is a major global health concern, contributing significantly to mortality.
  • Despite advancements, substantial global disparities in primary liver cancer (PLC) burden persist.
  • Understanding HBV-related liver disease trends is vital for public health strategies.

Purpose of the Study:

  • To evaluate global trends in the prevalence, incidence, and mortality of HBV-related liver disease.
  • To assess the changing landscape of acute HBV infection, HBV-related cirrhosis, and HBV-related PLC.
  • To identify regional disparities and temporal changes in HBV-related liver disease burden.

Main Methods:

  • Utilized data from the Global Burden of Disease Study 2021.
  • Analyzed prevalence, incidence, and death rates for acute HBV, HBV-related cirrhosis, and HBV-related PLC.
  • Examined age-standardized trends from 2000 to 2021, including regional analyses.

Main Results:

  • In 2021, HBV-related PLC represented 39% of global PLC incidence, with the Western Pacific region showing the highest rates.
  • Globally, age-standardized incidence, prevalence, and death rates of HBV-related liver disease decreased between 2000 and 2021.
  • However, the incidence of HBV-related PLC increased in 65 countries, with notable rises in Europe and the Americas.

Conclusions:

  • While overall HBV-related liver disease burden has decreased, a significant number of countries face rising HBV-related PLC incidence.
  • These divergent trends underscore the critical need for enhanced Hepatitis B virus (HBV) treatment interventions.
  • Strengthening HBV management is essential to mitigate the growing risk of liver cancer globally.