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Updated: May 28, 2025
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Vitamin B6 catabolism and psoriasis risk: a cross-sectional study
Ruimin Bai1, Xiaoqing Cheng2, Yajie Yang1
1Department of Dermatology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Background:
Psoriasis is a common autoimmune inflammatory disease. Vitamin B6 is crucial for the body's inflammatory response, yet the relationship between 4-pyridoxic acid (4-PA), pyridoxal 5'-phosphate (PLP) and vitamin B6 turnover (4-PA/PLP) in psoriasis remains unexplored.
Objectives:
To investigate the relationship of 4-PA, PLP and vitamin B6 catabolism with the risk of psoriasis.
Methods:
This cross-sectional study analysed records for 7540 participants from the US National Health and Nutrition Examination Survey. Vitamin B6 catabolism was assessed via the serum 4-PA to PLP ratio (4-PA/PLP). The primary outcome was psoriasis, evaluated using weighted univariate and multivariate logistic regression to determine odds ratios (OR) and 95% confidence intervals (CI). Subgroup analyses were performed by age, gender, body mass index (BMI), hypertension, dyslipidaemia and cardiovascular disease.
Results:
Of the participants, 208 had psoriasis. After adjusting for confounders, 4-PA levels in the 'cutoff above' group were positively associated with psoriasis (OR 1.51, 95% CI 1.03-2.20). Additionally, 4-PA/PLP correlated with an increased psoriasis risk (OR 1.82, 95% CI 1.02-3.26). However, PLP levels did not show a significant association. The positive link between 4-PA/PLP and psoriasis was consistent in individuals with BMI ≥ 25 kg m-² and hypertension, and in those without dyslipidaemia.
Conclusions:
The results revealed a significant association between 4-PA and 4-PA/PLP levels in the presence of psoriasis. However, further extensive prospective studies are necessary to establish causality.
