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[Acute isoniazid poisoning].

B Köster, U Bode, H P Weber

    Anasthesie, Intensivtherapie, Notfallmedizin
    |February 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Acute isoniazid intoxication can be fatal, causing seizures and coma. High-dose vitamin B6 therapy is crucial for managing this poisoning and its potential neurotoxic effects.

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    Area of Science:

    • Toxicology
    • Pharmacology
    • Neurology

    Background:

    • Isoniazid is a primary treatment for tuberculosis.
    • Acute isoniazid intoxication presents with severe symptoms like seizures, coma, and metabolic acidosis.
    • High mortality rates are associated with isoniazid overdose.

    Observation:

    • Neurotoxicity can occur due to isoniazid and its metabolites.
    • A case demonstrated delayed onset of neurotoxicity.
    • Clinical presentation includes vomiting, seizures, coma, and metabolic acidosis.

    Findings:

    • Metabolites of isoniazid contribute to its neurotoxic effects.
    • Delayed neurotoxicity is a potential complication of isoniazid intoxication.
    • High-dose vitamin B6 is a key therapeutic intervention.

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    Implications:

    • Clinicians should consider delayed neurotoxicity in isoniazid poisoning.
    • Prompt and high-dose vitamin B6 administration is vital for patient survival and recovery.
    • Understanding isoniazid metabolism is critical for managing overdose cases.