Related Experiment Video
Updated: May 28, 2025

Treatment of Ankle Osteoarthritis with Total Ankle Replacement Through a Lateral Transfibular Approach
Published on: January 24, 2018
Preoperative opioid dependence associated with increased costs and wound dehiscence following total ankle
Weston E McDonald1, Alexander S Guareschi1, Joshua L Morningstar1
1Medical University of South Carolina, Department of Orthopaedics and Physical Medicine, CSB 708, MSC 622, 96 Jonathan Lucas Street, Charleston, SC 29425, United States.
Introduction:
The purpose of this study is to evaluate the influence of chronic opioid dependence on postoperative outcomes following primary total ankle arthroplasty (TAA).
Methods:
The Nationwide Readmissions Database (NRD) was queried from 2016 to 2020 to identify 29,751 patients undergoing primary elective TAA with patients divided into cohorts based on the presence of preoperative opioid dependence (861 patients; 2.9 %).
Results:
The overall cohort was majority male (54.2 %) with mean age of 64.15 (range 17-90) years, and Charlson-Deyo Comorbidity Index score of 0.65 (range 0-12). Preoperative opioid dependence was significantly predictive of increased risk of wound dehiscence (OR=5.365; p < .001), adverse discharge (OR=1.443; p < .001), extended stay greater than 4 days (OR= 1.438; p < .001), and more than a $1000 increase in the total cost of admission (β= 1052.27; p = .027).
Conclusion:
Chronic preoperative opioid use was significantly predictive of higher rates of postoperative complications, LOS, and substantially higher cost of admission for TAA.
Level Of Evidence:
Level III, Retrospective Cohort Study.
More Related Videos
Related Concept Videos
Analgesia and Pain Management
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Parenteral Anesthetics: Overview
General Anesthesia: Overview
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...

