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Effects of time-restricted eating and resistance training on skeletal muscle tissue quantity, quality and function in
V M Alfaro-Magallanes1, M Medrano2, J Echarte2
1Institute for Sustainability & Food Chain Innovation, Department of Health Sciences, Public University of Navarre, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain; LFE Research Group, Department of Health and Human Performance, Faculty of Physical Activity and Sport Sciences, Universidad Politécnica de Madrid, Madrid, Spain.
Background & Aims:
Time-restricted eating (TRE) shows promise for weight loss and improving menopause-related body composition and cardiometabolic health, but its effects on skeletal muscle tissue (SMT) in postmenopausal women are unknown. This study investigates the effects of three weight loss interventions over 12 weeks on SMT quantity, quality, function, and cardiometabolic health in postmenopausal women with overweight/obesity, with effects persistence evaluated at a 12-month follow-up.
Methods And Results:
In this randomized controlled trial, 78 postmenopausal women (50-65 years; BMI 25-40 kg/m2; sedentary lifestyle; eating window ≥12 h/day; no severe metabolic impairments) will be recruited. Participants will be randomly assigned to one of three groups for 12 weeks: TRE, TRE + resistance training, or CR + resistance training. The TRE groups will reduce their eating window to 8 h and receive nutritional advice to adhere to a Mediterranean diet. The CR group will follow a personalized hypocaloric diet (-500 kcal/day). Resistance training groups will perform supervised resistance training 3 times/week.
Primary Outcome:
Change in SMT quantity measured by MRI at baseline and after 12 weeks.
Secondary Outcomes:
intermuscular adipose tissue (IMAT), strength, power, body weight and composition, and cardiometabolic risk factors.
Conclusion:
This study will illustrate the effects of TRE and TRE combined with resistance exercise compared with the currently recommended obesity-lifestyle treatment on SMT quantity, quality, function, and cardiometabolic markers. The results will offer insights into dietary strategies to combat obesity and metabolic diseases without increasing sarcopenia risk in postmenopausal women, a sparsely studied and particularly affected population.
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