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Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
Published on: February 23, 2017
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New Nanobioceramics Based on Hydroxyapatite for Biomedical Applications: Stability and Properties.
Carmen Steluta Ciobanu1, Daniela Predoi1, Simona Liliana Iconaru1
1National Institute of Materials Physics, Atomistilor Street, No. 405A, 077125 Magurele, Romania.
Nanomaterials (Basel, Switzerland)
|February 13, 2025
Summary
This study introduces novel lyophilized hydroxyapatite (HApLF) and zinc-doped hydroxyapatite (5ZnHApLF) bioceramics. The 5ZnHApLF demonstrated significant antimicrobial activity and both materials showed excellent biocompatibility, indicating potential for biomedical applications.
Area of Science:
- Biomaterials Science
- Materials Chemistry
- Nanotechnology
Background:
- Hydroxyapatite (HAp) is a key biomaterial for bone regeneration.
- Developing novel HAp-based bioceramics with enhanced properties is crucial for advanced biomedical applications.
- Lyophilization offers a unique method for processing HAp materials.
Purpose of the Study:
- To develop and characterize novel lyophilized hydroxyapatite (HApLF) and zinc-doped hydroxyapatite (5ZnHApLF) bioceramics.
- To evaluate the biological properties, including cell compatibility and antimicrobial activity, of the developed bioceramics.
- To explore the potential of these new bioceramics for biomedical applications.
Main Methods:
- Modified coprecipitation method followed by lyophilization for sample preparation.
- Characterization using ultrasound, X-ray diffraction (XRD), energy dispersive X-ray analysis (EDS), X-ray photoelectron spectroscopy (XPS), Fourier Transform Infrared Spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), and Scanning Acoustic Microscope (SAM).
- Biological evaluation using MG63 and human gingival fibroblasts (HGF-1) cell lines, and antimicrobial assays against *Escherichia coli*, *Staphylococcus aureus*, and *Candida albicans*.
Main Results:
- Successful synthesis of HApLF and 5ZnHApLF bioceramics using lyophilization for the first time.
- Comprehensive characterization confirmed the structure, composition, and morphology of the bioceramics.
- Both HApLF and 5ZnHApLF exhibited good cell viability and favored cell attachment and proliferation.
- 5ZnHApLF demonstrated significant antimicrobial activity against tested bacterial and fungal strains.
Conclusions:
- The developed lyophilized hydroxyapatite and zinc-doped hydroxyapatite bioceramics possess favorable biological and antimicrobial properties.
- The incorporation of zinc ions enhances the antimicrobial efficacy of hydroxyapatite.
- These novel bioceramics show great promise for the development of advanced materials in the biomedical field.
