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Effect of halothane on coronary collateral circulation.

M Sivarajan, G Bashein

    Anesthesiology
    |May 1, 1985
    PubMed
    Summary
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    Halothane anesthesia maintained coronary collateral blood flow in dogs at normal heart rates. However, tachycardia during halothane anesthesia severely reduced subendocardial blood flow in collateralized regions.

    Area of Science:

    • Cardiovascular Physiology
    • Anesthesiology

    Background:

    • Coronary collateral circulation is vital for myocardial perfusion during coronary artery occlusion.
    • Understanding the impact of anesthetics on collateral flow is crucial for patient management.

    Purpose of the Study:

    • To investigate the effects of halothane anesthesia on coronary collateral blood flow in a chronic canine model.
    • To assess the influence of tachycardia on collateral perfusion under halothane anesthesia.

    Main Methods:

    • A chronic canine model with coronary artery occlusion was established using Ameroid constrictors.
    • Regional myocardial blood flow was measured using radioactive microspheres.
    • Experiments involved halothane anesthesia, xylazine sedation, and pacing-induced tachycardia.

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    Main Results:

    • Halothane anesthesia maintained subendocardial perfusion in normal and collateralized myocardium at normal heart rates.
    • Tachycardia during halothane anesthesia significantly decreased collateral subendocardial blood flow, leading to mortality in some animals.
    • Control measurements during xylazine sedation showed a marked decrease in collateral subendocardial blood flow with tachycardia.

    Conclusions:

    • Coronary collateral blood flow is well-maintained during halothane anesthesia at normal heart rates in this canine model.
    • Tachycardia during halothane anesthesia poses a significant risk to collateral-dependent myocardium, impairing subendocardial perfusion.