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Related Concept Videos

Explicit Memories01:27

Explicit Memories

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Explicit memories, also known as declarative memories, are consciously remembered, recalled, and reported. Studying for a chemistry exam involves material that will become part of explicit memory. There are two types of explicit memory: episodic and semantic.
Episodic memory contains information about personally experienced events and is reported as a story. An example of episodic memory is recalling a birthday celebration. This type of memory includes the what, where, and when of an event, as...
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Role of Neurotransmitters in Memory01:23

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Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
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Selenium and Episodic Memory: The Moderating Role of Apolipoprotein E ε4.

Shin Gyeom Kim1, Musung Keum2, Young Min Choe2,3

  • 1Department of Neuropsychiatry, Soonchunhyang University Bucheon Hospital, Bucheon 14584, Republic of Korea.

Nutrients
|February 13, 2025
PubMed
Summary

Higher selenium levels correlate with better cognitive function in older adults. However, these benefits are most pronounced in individuals without the APOE4 gene variant, suggesting personalized nutritional strategies.

Keywords:
APOE4Alzheimer’s diseasecognitionepisodic memoryselenium

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Area of Science:

  • Neuroscience
  • Nutritional Science
  • Genetics

Background:

  • Selenium (Se) is a vital trace element with neuroprotective properties, combating oxidative stress via selenoproteins.
  • The apolipoprotein E ε4 allele (APOE4) is a major genetic risk factor for Alzheimer's disease (AD), associated with lower Se levels and reduced antioxidant capacity.
  • Understanding the interplay between Se status and APOE4 genotype is crucial for cognitive health in aging populations.

Purpose of the Study:

  • To investigate the association between serum selenium concentrations and cognitive performance in older adults.
  • To examine how apolipoprotein E ε4 (APOE4) allele status modifies the relationship between selenium and cognition.
  • To inform personalized nutritional strategies for cognitive health.

Main Methods:

  • Serum selenium levels were quantified using ICP-MS in 196 older adults.
  • Cognitive function was assessed using the CERAD neuropsychological battery, evaluating episodic memory, global cognition, and non-memory functions.
  • APOE genotyping was performed to determine participants' allele status.

Main Results:

  • Higher serum selenium concentrations were significantly associated with better episodic memory scores and overall cognitive performance (CERAD total score).
  • A significant interaction between selenium levels and APOE4 status was observed, particularly impacting episodic memory.
  • The cognitive benefits of selenium were more pronounced in individuals who were negative for the APOE4 allele.

Conclusions:

  • Selenium's impact on cognitive health is genotype-specific, highlighting the importance of considering genetic factors like APOE4 status.
  • Personalized nutritional interventions focusing on selenium levels may be beneficial, especially for APOE4-negative individuals.
  • Further research is warranted to explore the mechanisms underlying selenium's neuroprotective effects and its therapeutic potential in aging.