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Updated: May 28, 2025

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The Ferroxidase-Permease System for Transport of Iron Across Membranes: From Yeast to Humans
Matteo Amadei1, Fabio Polticelli2, Giovanni Musci3
1Department of Biochemical Sciences 'A. Rossi Fanelli', Sapienza University of Rome, 00185 Rome, Italy.
Abstract:
Transport of iron across the cell membrane is a tightly controlled process carried out by specific proteins in all living cells. In yeast and in mammals, a system formed by an enzyme with ferroxidase activity coupled to a membrane transporter supports iron uptake or iron efflux, respectively. Ferroxidase belongs to the family of blue multicopper oxidases, enzymes able to couple the one-electron oxidation of substrate(s) to full reduction of molecular oxygen to water. On the other hand, the permeases are widely different and are specific to Fe3+ and Fe2+ in yeast and multicellular organisms, respectively. This review will describe the yeast and human ferroxidase-permease systems, highlighting similarities and differences in structure, function and regulation of the respective protein components.
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