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Updated: May 28, 2025
MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
Published on: September 3, 2013
Correlations Between MR Apparent Diffusion Coefficients and PET Standard Uptake Values in Simultaneous MR-PET Imaging
Andrii Pozaruk1,2,3, Vitaliy Atamaniuk2, Kamlesh Pawar3,4
1Department of Photomedicine and Physical Chemistry, Institute of Medical Sciences, The Medical College of The University of Rzeszów, 35-310 Rzeszów, Poland.
Abstract:
This study evaluated the hypothesis that 68Ga-PSMA-11 PET SUV, obtained via an advanced DL approach, correlates better with MR ADC maps than values from conventional PET-MR. Additionally, we aimed to identify the optimal SUV threshold for maximum correlation with ADC values. A cohort of 32 prostate cancer patients underwent CT and corresponding PET-MR imaging. The dataset underwent K-fold cross-validation, dividing it into four folds. In each fold, 24 patients were used for training, and 8 for validation to create DL models. ADC maps from 27 out of 32 patients were successfully aligned with T2 images for detailed analysis, revealing an inverse correlation (ρ = -0.20 to -0.51) between ADC and SUV values in prostate cancer zones. Statistically significant differences in mean SUV values were observed between PETMRI and PETDL. DL-based SUV values show a stronger correlation with ADC than conventional PET-MR values in our investigation.
