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Zoom-in Dermoscopy for Facial Tumors
Martina D'Onghia1, Francesca Falcinelli1, Lorenzo Barbarossa1
1Dermatology Unit, Department of Medical, Surgical and Neurological Sciences, University of Siena, 51300 Siena, Italy.
Diagnostics (Basel, Switzerland)
|February 13, 2025
Summary
High-magnification dermoscopy and fluorescence-advanced videodermatoscopy improve facial lesion diagnosis. These advanced techniques, combined with standard dermoscopy, aid in differentiating malignant lentigo maligna/melanoma from benign conditions, potentially reducing unnecessary biopsies.
Area of Science:
- Dermatology
- Oncology
- Medical Imaging
Background:
- Facial lesions like lentigo maligna and lentigo maligna melanoma (LM/LMM) pose diagnostic challenges due to similarity to benign conditions.
- Standard dermoscopy has limitations in revealing cellular details, necessitating advanced imaging techniques.
Purpose of the Study:
- To evaluate the diagnostic role of standard dermoscopy (D30), high-magnification dermoscopy (D150), and fluorescence-advanced videodermatoscopy (FAV) for facial LM/LMM.
- To differentiate malignant LM/LMM from benign facial lesions using these dermoscopic methods.
Main Methods:
- Retrospective, observational, multicenter study of 85 patients with facial skin lesions.
- Comparison of D30, D150, and FAV in identifying specific dermoscopic features.
- Statistical analysis using Gwet AC1 concordance index and correct classification rate (CCR).
Main Results:
- LM/LMM showed distinct features at D30 (e.g., blue-white veil, regression structures, angulated lines).
- D150 revealed predominant roundish melanocytes and melanophages in LM/LMM.
- FAV identified large dendritic cells, isolated melanocytes, and free melanin in LM/LMM with high concordance to D150.
Conclusions:
- Integrating D30, D150, and FAV enhances diagnostic precision for facial lesions.
- Combining macroscopic and cellular insights from these techniques can reduce unnecessary biopsies.
- Further research is needed to validate these findings.
