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Exploring Hypercoagulability in Post-COVID Syndrome (PCS): An Attempt at Unraveling the Endothelial Dysfunction

Maxim Muys1, Anne Demulder1, Tatiana Besse-Hammer2

  • 1Laboratory of Hematology, CHU Brugmann, Université Libre de Bruxelles (ULB), 1020 Brussels, Belgium.

Journal of Clinical Medicine
|February 13, 2025
PubMed
Summary

Post-COVID syndrome (PCS) patients exhibit prolonged thrombo-inflammatory dysregulation, with elevated thrombin generation and abnormal von Willebrand factor (VWF)/ADAMTS13 ratios in some individuals. These findings highlight key coagulation abnormalities in long COVID.

Keywords:
ADAMTS-13hypercoagulable statelong COVIDpost-COVID syndromepost-acute sequelae of SARS-CoV-2 infectionthrombin generationthromboembolic riskthrombomodulinvon Willebrand factor

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