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Drug-Induced Serious Cutaneous Reactions in Hospitalized Patients: A Cross-Sectional Study
Warisara Jiamsathit1, Kansuda Bunarong2, Sonthiya Papenkort2
1Sirindhorn College of Public Health Khon Kaen, Faculty of Public Health and Allied Health Sciences, Praboromarajchanok Institute, Khon Kaen 40000, Thailand.
Journal of Clinical Medicine
|February 13, 2025
Summary
Serious cutaneous adverse drug reactions (ADRs), like anaphylaxis, are common and preventable. Underlying conditions and other medications increase ADR severity, highlighting the need for hospital-wide prevention strategies.
Area of Science:
- Pharmacovigilance
- Clinical Medicine
- Drug Safety
Background:
- Serious adverse drug reactions (ADRs) pose significant risks, including hospitalization and mortality.
- Preventable ADRs necessitate understanding their types, frequency, and contributing factors.
- This study focuses on serious cutaneous ADRs in a tertiary care setting.
Purpose of the Study:
- To determine the types and frequencies of serious cutaneous ADRs.
- To identify management and prevention strategies for serious cutaneous ADRs.
- To assess factors contributing to the severity of serious cutaneous ADRs.
Main Methods:
- Retrospective cross-sectional study of inpatients and outpatients.
- Data collected from medical records over three years.
- Identification of serious cutaneous ADRs using ICD-10 codes.
Main Results:
- Anaphylaxis (38.5%) and urticaria (30.2%) were the most frequent serious ADRs.
- Antibiotics were the most suspected drug group (45.0%).
- Underlying conditions and concomitant drug use were associated with increased ADR severity (p=0.031, p=0.044).
Conclusions:
- Anaphylaxis is the most common serious ADR.
- Patients with comorbidities and polypharmacy are at higher risk for severe ADRs.
- Hospital-wide promotion of ADR prevention is crucial to minimize harm and recurrence.
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