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Updated: May 28, 2025
08:19
Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
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Tumor Necrosis Factor-Alpha Inhibitor Use and Malignancy Risk: A Systematic Review and Patient Level Meta-Analysis.
Conor B Driscoll1, Jordan M Rich1, Dylan Isaacson1
1Department of Urology, Northwestern University Feinberg School of Medicine, 676 North St Clair Street, Suite 2300, Chicago, IL 60611, USA.
Cancers
|February 13, 2025
Summary
Tumor necrosis factor-alpha inhibitors (TNF-Is) are widely used for inflammatory diseases. Their applications continue to expand, highlighting their therapeutic importance and ongoing research.
Area of Science:
- Immunology
- Pharmacology
- Rheumatology
Background:
- Tumor necrosis factor-alpha inhibitors (TNF-Is) have been established as key treatments for chronic inflammatory conditions over the past 20 years.
- The therapeutic landscape for TNF-Is is continuously evolving with new indications and expanded off-label uses.
Purpose of the Study:
- To review the current status and expanding applications of TNF-Is in managing chronic inflammatory disorders.
- To provide an overview of the evolving role of TNF-Is in clinical practice.
Main Methods:
- Literature review of studies on TNF-Is in chronic inflammatory diseases.
- Analysis of clinical trial data and real-world evidence for TNF-I efficacy and safety.
- Synthesis of information on expanded indications and off-label uses.
Main Results:
- TNF-Is are integral to treating various inflammatory conditions, including rheumatoid arthritis, psoriatic arthritis, and inflammatory bowel disease.
- Evidence supports the efficacy of TNF-Is in numerous approved and off-label indications.
- Ongoing research explores novel applications and patient populations for TNF-I therapy.
Conclusions:
- TNF-Is remain a cornerstone therapy for chronic inflammation, with a demonstrated capacity for expanded clinical utility.
- The continued development and application of TNF-Is underscore their significant impact on patient outcomes in inflammatory diseases.
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