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Brain Metastasis in Endometrial Cancer: A Systematic Review.

Daniela Sambataro1,2, Vittorio Gebbia2, Annalisa Bonasera1

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Brain metastases from endometrial cancer are rare. Multimodal treatments combining surgery, radiotherapy, and chemotherapy show improved outcomes for these patients.

Keywords:
brain metastasisendometrial carcinomaimmune checkpoint inhibitorradiotherapystereotactic radiotherapytarget therapy

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Area of Science:

  • Oncology
  • Neurology
  • Gynecologic Oncology

Background:

  • Brain metastases (BMs) from endometrial cancer (EC) are infrequent and pose significant clinical challenges.
  • Limited standardized treatment guidelines exist for EC with BMs.

Purpose of the Study:

  • To systematically review the incidence, therapeutic strategies, and outcomes of BMs in EC patients.
  • To provide insights for clinical practice and guide future research in this rare condition.

Main Methods:

  • A comprehensive literature search adhering to PRISMA guidelines was performed.
  • Included 99 reports detailing 594 cases of EC with BMs, supplemented by additional registry data for incidence assessment.
  • Descriptive and quantitative analyses were conducted on incidence, treatment modalities, and survival.

Main Results:

  • Analysis of 594 EC BMs cases identified common disease characteristics and treatment approaches.
  • Treatment modalities included surgery, radiotherapy, chemotherapy, and combined approaches.
  • Multimodal strategies, alongside specific disease characteristics, significantly influenced survival outcomes.

Conclusions:

  • Endometrial cancer brain metastases are rare, necessitating personalized, multimodal treatment plans.
  • Future research should prioritize prospective trials and molecular profiling to enhance patient management.