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Updated: May 28, 2025

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma
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KEAP1-NRF2 Interaction in Cancer: Competitive Interactors and Their Role in Carcinogenesis

Marina Oskomić1, Antonija Tomić1, Lea Barbarić1

  • 1Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, 10000 Zagreb, Croatia.

Cancers
|February 13, 2025
PubMed

Insights

The American Cancer Society projects approximately 2 million new cancer diagnoses in the US for 2024. This estimate highlights the significant and ongoing public health challenge posed by cancer.

Area of Science:

  • Oncology
  • Public Health
  • Epidemiology

Background:

  • Cancer remains a leading cause of morbidity and mortality in the United States.
  • Accurate incidence estimates are crucial for resource allocation and public health planning.

Purpose of the Study:

  • To present the estimated number of new cancer cases in the US for the year 2024.
  • To provide a statistical overview of the projected cancer burden.

Main Methods:

  • Utilized data and statistical modeling from the American Cancer Society.
  • Analyzed trends and demographic factors to project new cancer cases.

Main Results:

  • An estimated 2,001,190 new cancer cases are projected for 2024.
  • This figure excludes non-melanoma skin cancers.

Conclusions:

  • The projected 2 million new cases underscore the persistent impact of cancer on the US population.
  • Continued research and prevention efforts are essential to combat the cancer epidemic.
Keywords:
KEAP1NRF2cancer developmentoxidative stressprotein–protein interactions

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