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Related Concept Videos

Increased Body Temperature01:25

Increased Body Temperature

6.4K
A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
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Methods of reducing fever01:22

Methods of reducing fever

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The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
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Decreased Body Temperature01:29

Decreased Body Temperature

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A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
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Types of Fever01:25

Types of Fever

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Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
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Thermoregulation01:26

Thermoregulation

2.9K
The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
2.9K
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

3.9K
Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
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Related Experiment Video

Updated: Apr 29, 2026

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
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Using the Tissue Impulse Response Function to Streamline Fractionated MRgFUS-Induced Hyperthermia.

Pauline C Guillemin1, Yacine M'Rad1, Giovanna Dipasquale2

  • 1Image Guided Interventions Laboratory, GR-949, Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland.

Cancers
|February 13, 2025
PubMed
Summary

A new method using Green's function optimizes magnetic resonance-guided focused ultrasound (MRgFUS) for hyperthermia cancer treatment. This approach reduces MRI monitoring, lowering costs and simplifying logistics for broader clinical adoption.

Keywords:
HIFUMRIhyperthermia therapy

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Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
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Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics
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Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics

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Related Experiment Videos

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Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics
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Area of Science:

  • Oncology
  • Medical Physics
  • Biomedical Engineering

Background:

  • Combining radiation therapy with hyperthermia, particularly MR-guided focused ultrasound (MRgFUS), can improve cancer treatment outcomes.
  • Current MRgFUS applications are mainly ablative, and frequent MRI guidance increases costs and complexity.
  • A streamlined workflow is needed to integrate MRgFUS hyperthermia more efficiently into radiation therapy.

Purpose of the Study:

  • To develop and validate a simplified workflow for repeated MRgFUS hyperthermia treatments.
  • To reduce reliance on continuous MRI thermometry feedback during treatments.
  • To optimize acoustic power settings in advance using an impulse response function (Green's function) approach.

Main Methods:

  • Implemented the Green's function approach in a perfused phantom simulating tissue for MRgFUS hyperthermia delivery.
  • Conducted 30 experiments using pre-calculated acoustic power settings for stable temperature control.
  • Performed retrospective analysis of patient thermometry data to assess clinical applicability and robustness.

Main Results:

  • Achieved consistent, stable hyperthermia (+7 °C for 15 min) across varied perfusion rates in phantom experiments.
  • Demonstrated superior temperature stability compared to conventional closed-loop MRI feedback methods.
  • Confirmed the method's noise robustness and clinical applicability through retrospective patient data analysis.

Conclusions:

  • The off-line Green's function approach simplifies MRgFUS hyperthermia integration into cancer treatment.
  • This method has the potential to significantly reduce treatment costs and logistical challenges.
  • Findings support broader adoption of MRgFUS hyperthermia as an adjuvant therapy in oncology.