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Pressure-induced bone resorption in the middle ear.

R A Chole, M D McGinn, S P Tinling

The Annals of Otology, Rhinology, and Laryngology

|March 1, 1985

Summary

Transmitted pressure, even without cholesteatoma, can cause bone resorption in the middle ear. This study found that localized pressure induced osteoclastic activity and bone loss in gerbils.

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Area of Science:

Otolaryngology
Orthopedics
Pathology

Background:

Osteoclastic activity and bone resorption are observed in cholesteatoma.
Transmitted pressure is a potential factor in inducing osteoclasts.

Purpose of the Study:

To investigate if transmitted pressure alone, without cholesteatoma, can cause localized bone resorption in the middle ear.

Main Methods:

Surgical grade silicone implants were placed in the middle ear of gerbils.
Gerbils did not have cholesteatoma.
Bone resorption was assessed in areas of implant pressure.

Main Results:

Bone resorption occurred exclusively in regions where implants applied pressure to the bone.
Pressures ranging from 50 to 120 mm Hg induced osteoclastic bone resorption.

Conclusions:

Transmitted pressure is a direct cause of osteoclastic bone resorption in the middle ear.
This finding has implications for understanding bone loss in middle ear conditions.

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