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Groomed Fingerprint Sebum Sampling: Reproducibility and Variability According to Anatomical Collection Region and

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Summary

Groomed fingerprint sebum lipids offer a reproducible, non-invasive source for disease biomarker research. Lipid profiles show minimal sex differences but vary by anatomical region, guiding future study designs.

Keywords:
biomarkersfingerprintlipidomicslipidsmachine learningmass spectrometrynoninvasive samplingsebumskin

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Area of Science:

  • Lipidomics
  • Biomarker Discovery
  • Dermatology

Background:

  • Sebum lipids from groomed fingerprints are a promising, yet underutilized, source for biomarker research.
  • Current understanding of sebum lipid sampling reproducibility and variability is limited, hindering routine application.

Purpose of the Study:

  • To evaluate the reproducibility of lipid profiles from groomed fingerprints using mass spectrometry.
  • To assess variations in sebum lipids based on biological sex and anatomical grooming region (cheek, neck, forehead).

Main Methods:

  • A workflow for collecting and analyzing sebum lipids from groomed fingerprints was employed.
  • 180 fingerprint samples from 30 participants were analyzed using mass spectrometry.
  • Supervised and unsupervised classification methods were used to analyze lipid changes.

Main Results:

  • The sebum lipid sampling protocol demonstrated satisfactory reproducibility.
  • Negligible differences in lipid profiles were observed between male and female participants.
  • Lipid profiles differed significantly based on anatomical grooming region, with cheek and forehead samples being more similar.

Conclusions:

  • Groomed fingerprint sebum lipid analysis is a reproducible method suitable for biomarker studies.
  • Biological sex does not significantly impact groomed fingerprint lipid profiles.
  • Anatomical region is a key factor influencing groomed fingerprint lipid profiles, informing sample collection strategies.