Harmonization of MRI sequences across ERN EpiCARE centers

Area of Science:

• Neurology
• Radiology
• Medical Imaging

Background:

• Neuroimaging is crucial for diagnosing epilepsy.
• The International League Against Epilepsy (ILAE) developed the harmonized neuroimaging of epilepsy structural sequences (HARNESS-MRI) protocol for standardized MRI acquisition.
• The European Reference Network for Rare and Complex Epilepsies (EpiCARE) comprises 50 expert centers across 26 countries.

Purpose of the Study:

• To assess adherence to the HARNESS-MRI protocol within EpiCARE centers.
• To evaluate the impact of the HARNESS-MRI protocol on MRI standardization in epilepsy diagnosis.
• To compare current adherence rates with previous findings from 2016.

Main Methods:

• A survey was distributed to EpiCARE centers regarding imaging and postprocessing practices for epilepsy patients.
• Descriptive analysis of survey responses was conducted.
• Results were compared against existing guidelines and a 2016 survey.

Main Results:

• 79% of EpiCARE centers adhere to the HARNESS-MRI protocol for all epilepsy patients.
• All centers acquire 3D T1-weighted sequences; 90% acquire 3D FLAIR, and 87% acquire high in-plane 2D coronal T2 MRI sequences.
• Adherence has significantly increased from 50% in 2016.

Conclusions:

• There is increased harmonization of MRI sequences in European expert epilepsy centers since the HARNESS-MRI protocol's introduction.
• Standardization of MRI imaging improves radiological review and enables multicenter research datasets.
• This standardization supports optimal epilepsy diagnosis across Europe.