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The role of single-pill ACE inhibitor/ccb combination for hypertension: an Algerian view via the nominal group

Brahim Kichou1, Abed Bouraghda2, Hadj Mohamed Ali Lahmar3

  • 1Cardiology Department, University Hospital of Tizi Ouzou, Tizi Ouzou, Algeria.

Future Cardiology
|February 13, 2025
PubMed

Insights

A new single-pill combination of perindopril/amlodipine offers a valuable treatment option for hypertension management in Algeria. This combination effectively controls blood pressure and reduces cardiovascular risks, improving patient outcomes.

Area of Science:

  • Cardiology
  • Pharmacology
  • Public Health

Background:

  • Hypertension affects one-third of Algerian adults, with over 40% undiagnosed.
  • Adequate blood pressure control is achieved in only 20-30% of treated patients in Algeria.

Purpose of the Study:

  • To evaluate the clinical evidence for a new perindopril/amlodipine single-pill combination (SPC).
  • To determine the role of this ACEi/CCB combination in Algerian hypertension management.

Main Methods:

  • Review of clinical evidence by twelve Algerian hypertension experts.
  • Assessment of the perindopril/amlodipine SPC's efficacy and tolerability.

Main Results:

  • The perindopril/amlodipine SPC demonstrated reduction in cardiovascular outcomes.
  • Effective 24-hour blood pressure control and reduced visit-to-visit variability were observed.
  • The combination was found to be well tolerated.

Conclusions:

  • The perindopril/amlodipine SPC is a valuable new therapeutic option for hypertension in Algeria.
  • This combination addresses the need for improved blood pressure management and patient outcomes.

Keywords:
AlgeriaNorth Africaamlodipinecardiovascular diseasehypertensionmortalityperindopril

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