Associations of Pretransplant Patient-Reported Outcomes Measurement Information System Physical Function Score With...

Area of Science:

• Nephrology
• Transplantation
• Rehabilitation Medicine

Background:

• Pretransplant low physical function is a common, modifiable risk factor in kidney transplant candidates.
• Simple and validated physical function measures are crucial for this population.
• The Patient-Reported Outcomes Measurement Information System® Physical Function (PROMIS-PF) is a potential tool.

Purpose of the Study:

• To investigate the association between pretransplant physical function (assessed by PROMIS-PF) and early posttransplant outcomes.
• To evaluate the utility of PROMIS-PF in identifying kidney transplant candidates.
• To explore the potential for pretransplant prehabilitation.

Main Methods:

• Single-center retrospective study.
• Analyzed 154 adult kidney-alone transplant recipients.
• Assessed pretransplant physical function using PROMIS-PF computer adaptive testing.

Main Results:

• PROMIS-PF scores were not associated with transplant length of stay, graft function, or survival.
• Lower PROMIS-PF scores were significantly linked to increased risk of emergency room visits within 1 month posttransplant.
• Lower PROMIS-PF scores were significantly linked to increased risk of rehospitalization within 1 month posttransplant.

Conclusions:

• PROMIS-PF is a practical tool for assessing physical function in kidney transplant candidates.
• PROMIS-PF may help identify candidates at higher risk for early posttransplant adverse events.
• Larger studies are needed to confirm PROMIS-PF's utility in guiding pretransplant prehabilitation.