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Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
07:06

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Faecal microbiota transplantation for eradicating Helicobacter pylori infection: clinical practice and theoretical

Zhi-Ning Ye1, Guy D Eslick2, Shao-Gang Huang3

  • 1The Affiliated Dongguan Hospital of Guangzhou University of Chinese Medicine, Dongguan, China.

Egastroenterology
|February 13, 2025
PubMed

Insights

Faecal microbiota transplantation (FMT) shows promise for eradicating Helicobacter pylori (H. pylori) infections, offering a new approach when antibiotics fail. Research is ongoing to optimize FMT protocols for maximum effectiveness against H. pylori.

Area of Science:

  • Microbiology
  • Gastroenterology
  • Immunology

Background:

  • Antibiotic resistance is decreasing the effectiveness of standard treatments for *Helicobacter pylori* (*H. pylori*) infections.
  • Single probiotic administration has shown minimal success in eradicating *H. pylori*.

Purpose of the Study:

  • To review the efficacy of faecal microbiota transplantation (FMT) as a therapeutic strategy for *H. pylori* eradication.
  • To explore the potential mechanisms and influencing factors of FMT in treating *H. pylori* infection.

Main Methods:

  • Review of existing literature on FMT for *H. pylori* eradication.
  • Analysis of FMT's role as monotherapy and adjunctive therapy.

Main Results:

  • FMT demonstrates beneficial effects in eradicating *H. pylori* and preventing adverse events.
  • The efficacy of FMT may be attributed to various components within the fecal suspension, such as microbes and metabolites.
  • Donor selection, preparation, and delivery methods significantly impact FMT effectiveness.

Conclusions:

  • FMT presents a promising therapeutic option for *H. pylori* infection, particularly in the context of rising antibiotic resistance.
  • Further research is needed to optimize FMT procedures and elucidate its precise mechanisms of action against *H. pylori*.
Keywords:
Digestive System DiseasesGastrointestinal MicrobiomeHelicobacter pyloriInfections

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