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Related Experiment Videos

Sleep apnea in active acromegaly.

T B Hart, S K Radow, W G Blackard

    Archives of Internal Medicine
    |May 1, 1985
    PubMed
    Summary

    Active acromegaly is linked to sleep apnea syndrome (SAS). Successful treatment normalizing growth hormone (GH) levels may resolve SAS, suggesting GH elevation contributes to this condition.

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    Area of Science:

    • Endocrinology
    • Sleep Medicine
    • Respiratory Physiology

    Background:

    • Previous reports suggest a link between acromegaly and sleep apnea syndrome (SAS).
    • Central SAS in some patients raises questions about growth hormone (GH) effects on respiratory drive.

    Purpose of the Study:

    • To determine the prevalence of SAS in patients with acromegaly.
    • To investigate the relationship between GH levels and SAS in acromegaly patients.
    • To assess the impact of GH on hypercapnic ventilatory response.

    Main Methods:

    • Studied 21 acromegaly patients, divided into active (high GH) and inactive (normal GH) groups.
    • Assessed for SAS using polysomnography.
    • Measured hypercapnic ventilatory response in all patients.

    Main Results:

    • SAS was present in 40% of patients with active acromegaly (4/10).
    • No SAS was observed in patients with inactive acromegaly (0/11).
    • SAS types included obstructive and mixed central/obstructive; hypercapnic ventilatory response remained normal regardless of GH levels.

    Conclusions:

    • Sleep apnea syndrome is associated with active acromegaly.
    • Growth hormone levels do not appear to influence hypercapnic ventilatory response.
    • Resolution of SAS after successful acromegaly treatment suggests reversibility.

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