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Updated: May 10, 2026
Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
Inhibition of miMOMP-induced SASP to combat age-related disease
Xiaoli Liao1, Zhennan Guo1,2, Mouhai He1
1School of Medical Technology and Nursing, Hunan institute of traffic engineering, Hengyang, China.
Abstract:
Cellular senescence, first described in 1961, was initially observed in normal human fibroblasts that ceased proliferating after a finite number of divisions in culture. This process is triggered by various stimuli, including oxidative stress, chromatin modifications and oncogene activation, characterized by irreversible cell-cycle arrest, resistance to apoptosis and the induction of a complex senescent associated secretory phenotype (SASP). Over the past decade, emerging evidence has linked cellular senescence to the aging process and a wide range of chronic age-related diseases. Consequently, research focused on targeting senescence to alleviate or delay age-related disease, referred to as senotherapy, has been conducted rapidly. Therefore, elucidating the mechanisms of cellular senescence is essential for providing practical strategies aimed at addressing this condition.
Insights
Cellular senescence, a state of irreversible cell arrest, is linked to aging and diseases. Understanding its mechanisms is key for developing senotherapy to combat age-related conditions.
Area of Science:
- Cellular and Molecular Biology
- Gerontology
- Biomedical Science
Background:
- Cellular senescence, identified in 1961, involves normal human fibroblasts ceasing proliferation.
- This process is triggered by stimuli like oxidative stress and oncogene activation.
- Senescence is characterized by cell-cycle arrest, apoptosis resistance, and a unique secretory phenotype (SASP).
Purpose of the Study:
- To elucidate the mechanisms underlying cellular senescence.
- To explore the link between cellular senescence, aging, and age-related diseases.
- To inform the development of senotherapy for age-related conditions.
Main Methods:
- Review of historical and recent research on cellular senescence.
- Analysis of triggers and characteristics of senescence.
- Examination of the role of senescence in aging and disease.
Main Results:
- Cellular senescence is a complex process triggered by various stressors.
- Senescence is implicated in the aging process and numerous chronic diseases.
- Targeting senescence (senotherapy) shows promise for age-related disease intervention.
Conclusions:
- Elucidating senescence mechanisms is crucial for advancing senotherapy.
- Cellular senescence represents a significant target for therapeutic strategies against aging and related diseases.
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