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Peripheral blood immunoinflammatory biomarkers: prospective predictors of postoperative long-term survival and chronic postsurgical pain in breast cancer

  • 0Department of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Frontiers in Immunology +

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February 13, 2025

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February 13, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Elevated preoperative Systemic Inflammation Response Index (SIRI) predicts poor disease-free survival in breast cancer patients. However, perioperative inflammatory biomarkers showed limited ability to predict chronic postsurgical pain (CPSP).

Area Of Science

  • Oncology
  • Immunology
  • Surgical Research

Background

  • Inflammation significantly impacts breast cancer progression and chronic postsurgical pain (CPSP).
  • The predictive value of immunoinflammatory biomarkers for long-term survival and CPSP is not fully understood.

Purpose Of The Study

  • To investigate the predictive value of preoperative immunoinflammatory biomarkers for long-term survival in breast cancer patients.
  • To assess the association between perioperative immunoinflammatory biomarkers and the occurrence of CPSP.

Main Methods

  • Retrospective analysis of 80 breast cancer surgery patients, collecting clinicopathological and perioperative peripheral blood immunoinflammatory biomarker data.
  • Established optimal cut-off values for preoperative biomarkers (SII, SIRI, NLR, PIV) using ROC curves.
  • Utilized Kaplan-Meier curves, Cox regression, and logistic regression to analyze survival and CPSP relationships.

Main Results

  • Lower preoperative SII, SIRI, NLR, and PIV were associated with prolonged disease-free survival (DFS) and overall survival (OS).
  • Elevated preoperative SIRI independently predicted poor DFS (HR=8.890, P=0.038).
  • Body mass index (BMI) was the only independent predictor of CPSP (OR=0.262, P=0.023), with no significant association found for perioperative inflammatory biomarkers.

Conclusions

  • Preoperative SIRI is a significant independent risk factor for reduced DFS in breast cancer patients post-surgery.
  • Perioperative immunoinflammatory biomarkers have limited predictive value for CPSP in breast cancer patients undergoing surgery.

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